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Study finds lack of complete TB drug-susceptibility data can lead to resistance amplificatio



Last Updated on April 18, 2024 by Robert C. Hoopes

A recent study conducted by a start-up from IIT Mumbai and Dr. D.Y. Patil Medical College has revealed alarming findings about the prevalence of pre-extensively drug-resistant TB (pre-XDR-TB) in presumptive multi-drug resistant (MDR) tuberculosis cases in India.

The study, which involved whole genome sequencing of 600 clinical samples from TB patients in the country, found that nearly 51% of cases had pre-XDR-TB and 15.5% had MDR-TB. Surprisingly, these drug-resistant strains were found in equal proportions among men and women.

Extensively drug-resistant TB (XDR-TB), which is resistant to isoniazid, rifampicin, fluoroquinolones, and at least one injectable second-line drug, poses a major threat to public health. With over 29.5 lakh active TB cases reported in India in 2020, the emergence of drug-resistant strains further complicates the fight against this infectious disease.

The study also found resistance not only to rifampicin and isoniazid, but also to fluoroquinolones, highlighting the urgent need to revisit the conventional approach to TB management. Anirvan Chatterjee, CEO and co-founder at Haystack Analytics, stressed the importance of these findings and the need for a new strategy to combat drug-resistant TB.

TB remains the second leading infectious disease killer globally, making it imperative for healthcare professionals and policymakers to address the growing threat of drug-resistant strains. The study’s results underscore the critical need for innovative solutions to tackle TB dynamics in India and around the world.

Dina J. Miller is an accomplished writer and editor with a passion for business and education. With over a decade of experience in the industry, she has established herself as a leading voice in the MBA community. Her work can be found in a variety of MBA magazines and college publications, where she provides insightful commentary on current trends and issues in the field. Dina's expertise in business and education stems from her extensive academic background. She holds a Master's degree in Business Administration from a top-tier business school, where she excelled in her studies and developed a deep understanding of the complexities of the business world. Her academic achievements have been recognized with numerous awards and honors, including induction into several prestigious academic societies.

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